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Fast dissolving tablets PPT

Fast dissolving tablets

.pptx   Fast dissolving.pptx (Size: 100.18 KB / Downloads: 55)


Fast Dissolving Tablets (FDTs) or “mouth dissolving tablets” (MDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth.


It offer all advantages of solid dosage forms and liquid dosage forms along with special advantages, includes
It provide good stability, accurate dosing, easy manufacturing, small packaging size & easy to handle.
No need of water to swallow the dosage form.
Easy to administer for paediatric, geriatric & institutionalized patients.
More rapid drug absorption from the pre-gastric area which may produce Quick onset of action.
Pre-gastric absorption of drug avoids hepatic metabolism, which reduces the dose and increase the bioavailability.
The risk of chocking or suffocation during oral administration avoided.
Good mouth feel property of MDDDS helps to change the basic view of medication as "bitter pill"
Patient’s compliance for disabled bedridden patients and for travelling and busy people, who do not have ready access to water.

Requirements of ODTs

Dissolve / disintegrate in the mouth in matter of seconds without water.
Have sufficient mechanical strength and good package design.
Not affected by drug properties.
Effective taste masking technologies should be adopted for bitter taste drugs.
Leave minimal or no residue in mouth after oral administration.
Exhibit low sensitivity to environment condition such as humidity and temperature
Rapidly disintegrating tablets (FDTs) have received increasing demand over the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral administration of drugs remains the preferred route of administration of various drugs. Recent developments in technology have led scientists to develop FDTs with better patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for the easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in the development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs or oral disintegrating tablets provide an advantage particularly for pediatric and geriatric populations having difficulty swallowing conventional tablets and capsules. This review describes various formulations and technologies developed to achieve rapid dissolution / dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilisation, molding, sublimation and compaction, as well as approaches for improving FDT properties, such as spray drying and the use of disintegrants.

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